C. ELEGANS ZHP-4 IS REQUIRED AT MULTIPLE DISTINCT STEPS IN THE FORMATION OF CROSSOVERS AND THEIR TRANSITION TO SEGREGATION COMPETENT CHIASMATA.

C. elegans ZHP-4 is required at multiple distinct steps in the formation of crossovers and their transition to segregation competent chiasmata.

Correct segregation of meiotic chromosomes depends on DNA crossovers (COs) between homologs that culminate into visible physical linkages called chiasmata.COs emerge from a larger population of joint molecules (JM), the remainder of which are repaired as noncrossovers (NCOs) to restore genomic integrity.We present evidence that the RNF212-like C.el

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